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I hereby certify that this correspondence is being deposited with the United 
States Postal Service first class mail in an envelope addressed to: 
Mail Stop Petition; Commissioner for Patents, P.O. Box 1450, Alexandria, VA 
22313-1450, on 



By: 




Sharon M. Fujita 



Attorney Docket No: 0178.210US 



IN THE UNITED STATES PATENT AND TRADEMARK OFFICE 



In re application of: 
Minshull, et al 
Application No.: 09/920,607 
Filed: July 31, 2001 

For: BIOSENSORS, REAGENTS AND DIAGNOSTIC 
APPLICATIONS OF DIRECTED EVOLUTION 



Mail Stop Petition 
Commissioner for Patents 
P.O. Box 1450 
Alexandria, VA 22313-1450 



Examiner: My-Chau T. Tran 
Art Unit: 1639 

RESPONSE TO FURTHER 
RESTRICTION REQUIREMENT 

RECEIVED 

JUL 3 0 2003 
OFFICE OF PETITIOI^ 



Dear Sir: 

Responsive to the Restriction Requirement mailed January 13, 2003, Applicants 
respectfully request consideration of the following remarks. A petition for a five month extension 
of time authorizing the Commissioner to charge the requisite fee pursuant 37 C.F.R. § 1.17 is 
enclosed. The petition thus effectively extends the period of response from February 13, 2003 to 
July 13, 2003. A Petition for Revival of an Application for Patent Abandoned Unintentionally 
under 37 C.F.R. § 1.137(b) is also submitted herewith. 

In the Restriction Requirement mailed on January 13, 2003, the Examiner issued a further 
Restriction Requirement on Applicants' previously elected Group II claims (67-72). In the January 
13, 2003 Restriction Requirement, the Examiner grouped claims 67-72 as follows: 

Group A: Claim 67, drawn to a biosensor with a polypeptide comprising an analyte 
domain and a catalytic domain; 

Group B: Claim 68, drawn to a biosensor with a polypeptide comprising an analyte 
domain, a first inactive domain, and a second inactive domain; and 



Application No.: 09/92cPf7 
Filing Date: September 19, 2002 
Page 2 of 2 



Group C: 



Claims 69-72, drawn to a biosensor with a plurality of polypeptides 
immobilized on the solid support. 



Applicants hereby elect the inventions specified in Group C, without traverse. 

Should the Examiner believe that a telephone conference would expedite the prosecution of 
this application, the undersigned can be reached at the telephone number set forth below. The 
Commissioner is hereby authorized to charge any deficiency in fees in connection with this 
submission or credit any overpayment to Deposit Account No. 50-0990. 



515 Galveston Drive 
Redwood City, Cahfomia 94063 
(650) 298-5421 (Telephone) 
(650) 298-5446 (Facsimile) 
Customer No. 30560 



RespectfiiUy submitted, 



July^, 2003 




MAXYGEN, INC. 

Intellectual Property Department 



Sharon M. Fujita 
Attorney for Applicants 
Reg. No. 38,459